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The UNITRAD cooperative group was created in 2014. It brings together experts from various disciplines such as radiation oncologists, physicists, dosimetrists, radiobiologists and statisticians.  UNITRAD aims to develop strategic guidance in radiation therapy, to set up multidisciplinary collaborative networks in France and abroad, and to stimulate and organize innovative research programs. This group is open to all researchers interested in the development of knowledge in the different fields of radiation oncology.

UNITRAD promotes a research program in oncologic radiation therapy including clinically dedicated radiotherapy, applied radiophysics, brachytherapy, innovative technologies and combinations of ionizing radiation and systemic treatments including targeted therapies and immunotherapy.

UNITRAD as a transverse Group closely interacts with the other Unicancer expert groups, pooling their respective networks as well as their biological, methodological and technical expertise, with the goal to conduct innovative and strategic clinical studies with a strong translational component in a standardized fashion.

Within UNITRAD, five working groups are dedicated to

  • defining and coordinating a translational strategic program of biological samples/radiotherapy and imaging data collections and valorisation
  • harmonising the radiatiotherapy practices
  • optimizing the Quality Assurance of medical imaging and radiotherapy.
UNITRAD becomes the leading European group in the field of radiotherapy research.

Several translational projects are under development, in the fields of artificial intelligence, radiobiology and immunology, PROMs/real life data, quality assurance of radiotherapy.

Approximately 100  multidisciplinary experts already joined UNITRAD

7 ongoing clinical trials with over 1500 patients enrolled.

6 communications at international congresses.

UNITRAD members

UNITRAD is composed of members with various specialties (Radiation Oncologists, physicists, dosimetrists, statisticians, radiobiologists, radiotherapy quality assurance specialists…, ) and with relevant experience in radiation oncology clinical trials. Members represent the various institutions (FCCC, University Hospital, private centres) participating in clinical trials and in the definition of the group strategy.

The main missions of this steering committee are to :

  • Define the strategic orientations, initiate and organize innovative research programs in the field of radiation therapy
  • Stimulate interactions with the various players involved in radiation therapy research and facilitate the creation of specific networks (research groups under the aegis of Unicancer, fundamental, preclinical and translational research laboratories associated with Unicancer Network Centres, clinical research investigators inside and outside the Unicancer network, international groups)
  • Evaluate study proposals prior to their validation according to Unicancer’s usual procedures
  • Validate the scientific value of the studies
  • Propose and build prospective clinical trials & surveys or retrospective studies
  • Conduct national and international clinical studies in radiation oncology,
  • Identify and involve beforehand all experts in the design of the studies

The steering committee is composed of a chairperson, a restricted bureau composed of 4 persons (including a vice-chairperson and a secretary), 5 working groups’ coordinators and a minimum of 15 members.

Five working groups/expert groups

  • Artificial intelligence (AI): radiomics, medical imaging – Coordinators: Dr. David Pasquier (Oscar Lambret Centre, Lille) and Charlotte Robert (Gustave Roussy)
  • Radiobiology: immuno-radiotherapy, radiosensitivity, radio-potentiation – Coordinator: Céline Mirjolet (Centre Georges François Leclerc – Dijon)
  • New technologies and development in physics – Coordinators: Pr. Juliette Thariat (Caen) and Marie-Claude BISTON (Centre Léon Bérard)
  • Quality assurance in radiotherapy/safety: Albert Lisbona (Institut de Cancérologie de L’Ouest)
  • PROMs/real world data: Dr Sébastien Guihard – ICANS – Strasbourg

Strategic priorities

  • Integration of biological and physical phenomena;
  • Evaluation of new dose delivery techniques using external radiotherapy techniques (e.g. intensity-modulated radiation therapy), stereotactic radiotherapy, brachytherapy, intraoperative radiation therapy, proton therapy, MRI-Linac;
  • New combinations of radiotherapy with systemic treatments (e.g. targeted therapies or immunotherapies);
  • Standardization of radiotherapy practices.

UNITRAD promotes an active quality approach and collaborates with companies experts in the field of Quality Assurance and artificial intelligence for medical imaging and radiotherapy in order to guarantee a very high level of quality:

  • Clinical data and images storage on a secured platform.
  • Efficient image registration and contouring.
  • Data farming and analysis.

Flagship projects


This a non-inferiority phase III open-label, randomized, controlled multicentric trial comparing hypofractioned versus standard radiotherapy in breast cancer with an indication for regional lymph node irradiation in terms of lymphedema occurrence. From September 2016 to March 2020, 1265 patients have been included in this trial. The first results will be published in 2021.


A collaborative project between UNITRAD and Therapanacea, a start-up that spun out of world-renowned centres in radiotherapy and artificial intelligence (AI) research, has been launched in 2019.

The project aims at developing and implementing a new-generation of quality control tool using AI technologies that will enable to automatize, generalize and standardize the verifications of organs-at-risk (OAR) and target volumes delineation for cancer patients treated by radiotherapy in the framework of academic or industrial clinical trials.  Currently, verification of delineation is a manual and time-consuming process that can only be performed for a handful of patients cases included in a trial. However, the quality of delineation in those trials is decisive to the following steps of the trials and successful analysis of their results.

This novel tool uses the quality of contouring of Breast anatomy conducted during HYPOG-01 trial. UNITRAD provided data and expertise in order for Therapanacea to develop and validate the QC tool.

The first results of this collaborative project have been presented in international congresses in 2020 (ESTRO/ASTRO).

The successful realization of the project shall lead to a revolution and immediate benefit to all cancer-related clinical trials that include radiotherapy data through massive gain of time, and maximum increase in quality of data injected in the trial, through the ability to apply quality control procedures to all new included patient data without additional effort or cost.


This is a Phase II, international, randomised, controlled, open-label, multicentric, parallel trial assessing the efficacy and safety of adding upfront stereotactic radiosurgery (SRS) to binimetinib-encorafenib plus pembrolizumab combination therapy in the treatment of BRAFV600 mutation-positive melanoma with brain metastasis. The recruitment is this study is planned in Q4 2021.

The study is supported financially by Pierre Fabre Medicaments.


This is an open-labelled, randomized, multicentric phase III study comparing pembrolizumab & chemotherapy with radiotherapy versus pembrolizumab & chemotherapy alone in patients with advanced non-small cell lung cancer. 510 patients are expected to be enrolled. Recruitment in this study is still ongoing.

Microbiota translational research of Nirvana-Lung study is part of Oncobiome project which is supported by the European Union’s Horizon 2020 grant.

How to propose a research project?

Anyone specialised in radiation oncology area can propose a study. UNITRAD steering committee has all the experts who can help develop your project.

The criteria for acceptance/refusal of a study/trial to be developped within UNITRAD are transparent and are as follows:

  • Adequacy or not to the strategy of the Intergroup
  • Innovation and originality
  • Medical, technical and financial feasibility

Circuit for the development of new tests/studies

The proposal must be written in the form of a synopsis, by e-mail to the Unicancer Clinical Programme Lead.

The synopsis should include: title and acronym, objectives, end points, inclusion and exclusion criteria, study design, treatments under study if applicable, scientific background, statistical hypotheses, estimated costs (if available) and type of financial support envisaged.

The synopsis can be written in English.

Proposals remain confidential within UNITRAD Steering committee. All members have signed a confidentiality agreement.

The project leader will be invited to discuss his/her proposal during a steering committee meeting or during the annual general assembly.

After validation, the trial can be implemented with the help of the Unicancer project unit.


International partners

UNITRAD is increasing involvement in international trials in collaboration with the main cooperative groups abroad at the European (EORTC, EADO) as well as international (CCTG, ongoing collaboration) level, UNITRAD is becoming a key international player in clinical research on radiation oncology field.


Flagship programs